Claire Simmons (Jennifer Aniston) lives in chronic pain - and none too pleasantly; her abrasive anger has driven virtually everyone out of her life except for housekeeper Silvana (Adriana Barraza). But the suicide of a fellow chronic-pain sufferer (Anna Kendrick) shakes Claire to the core, and in trying to understand the death of a woman she barely knew, she may finally come to grips with her own life.