Spiraling between grimy horror, punk rock and art film, Abel Ferrara directs and stars as Remo Miller, a starving artist struggling to make it in NYC. As the pressure mounts, his sanity slips, and the only way to fulfill his artist craving is by taking a power drill to anyone he encounters on the streets late at night. As the opening title card says: "This Film Should Be Played Loud," so prepare for mayhem at maximum volume.

Thana (Zoë Lund), a mute seamstress in the fashion industry in the heart of New York’s rotten Big Apple, has her world destroyed when she is assaulted twice in one day. Her innocence lost, she seeks vengeance and takes to the gritty streets, luring would-be rapists and criminal scumbags to their demise with a blast from her .45-caliber pistol.